Fig 1.
Serial H&E (A,C) and BAP1 IHC (B, D) stained sections of pancreatic ductal adenocarcinomas which demonstrate positive immunohistochemical staining for BAP1.
All the neoplastic and non-neoplastic cell demonstrate diffuse strong nuclear staining (Original magnification A,B 100x, C,D 400x).
Fig 2.
Haematoxylin & eosin (A, C) and BAP1 immunohistochemistry (B, D) stained sections from the sole pancreatic ductal adenocarcinoma patient who expressed loss of nuclear BAP1.
In this case, the exocrine cells (solid arrows) clearly lacked the brown BAP1 staining, and the non-neoplastic endothelial cells serve as the internal positive controls (hollow arrows). Magnifications: A, B 100x; C, D 400x.
Table 1.
Clinical and pathological characteristics of 306 pancreatic adenocarcinoma patients.
Fig 3.
Kaplan-Meier survival curve for 306 pancreatic ductal adenocarcinoma patients.
Table 2.
Univariate and multivariate Cox regression proportional hazards analysis of 306 pancreatic adenocarcinoma patients.