Fig 1.
Flow-chart of patients included.
Table 1.
Main clinical and biological data of the 70 patients at baseline and during the treatment.
Fig 2.
Renal handling of creatinine before and after introduction of Vemurafenib.
For each patient and each visit, the black part of the bar represents GFR (urinary clearance of 51CrEDTA) and the grey part of the bar represents the proportion of creatinine clearance due to secretion, the whole bar representing overall urinary clearance of creatinine. For each patient, the proportion of clearance of creatinine due to its secretion decreased under Vemurafinib treatment by 55, 43 and 81% for patients 1, 2 and 3 respectively.
Table 2.
Renal function before and after introduction of Vemurafenib.
Fig 3.
Decision-tree to manage elevation of creatinine under Vemurafenib.