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Table 1.

Study Design.

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Fig 1.

Percentage of public and private HCE of GDP (pie) in the US and Germany in 2013.

Thin lines, public HCE; bold lines, private HCE without out-of-pocket; black fill, out-of-pocket HCE; white fill, rest of GDP (non-HCE) HCE, healthcare expenditure; GDP, gross domestic product; $B, US$ billion.

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Fig 2.

(A) Percentage of HCE on IVD in 2013 and (B) evolution of HCE on IVD 1993–2013. HCE, healthcare expenditure; IVD, in vitro diagnostics; $ B, US$ billion.

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Fig 2 Expand

Table 2.

Number of Patients Receiving IVD Testing per Week and General Use of IVD Testing During Different Phases of Care.

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Table 2 Expand

Table 3.

Physicians’ estimation of IVD expenditure as a proportion of total HCE.

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Table 3 Expand

Table 4.

Relationship between percentage of clinical decisions based on IVD testing and perceived HCE on IVDs by physicians.

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Fig 3.

Causal loop diagram displaying the root causes for over- and under-utilization of IVD testing. Key drivers displayed in boxes; antecedents and secondary drivers displayed as plain text.

IVD, in vitro diagnostic; →(+), positive causal links amplifying the behavior of target variable.

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Fig 3 Expand