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Fig 1.

CONSORT diagram of the review process.

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Fig 1 Expand

Fig 2.

Adaptive signature design.

“R” refers to randomization of patients.

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Fig 2 Expand

Fig 3.

Outcome-based adaptive randomization design.

“R” refers to randomization of patients.

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Fig 3 Expand

Fig 4.

Adaptive threshold sample-enrichment design.

“R” refers to randomization of patients.

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Fig 4 Expand

Fig 5.

Adaptive patient enrichment design.

“R” refers to randomization of patients.

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Fig 5 Expand

Fig 6.

Adaptive parallel Simon two-stage design.

“R” refers to randomization of patients.

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Fig 6 Expand

Fig 7.

Multi-arm multi-stage (MAMS) design.

“R” refers to randomization of patients.

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Fig 7 Expand

Fig 8.

Stratified adaptive design.

“R” refers to randomization of patients.

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Fig 8 Expand

Fig 9.

Tandem two stage design.

“R” refers to randomization of patients.

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Fig 9 Expand

Table 1.

Characteristics of biomarker-guided adaptive trial designs in Phase II and Phase III.

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Table 1 Expand