Table 1.
Patient Demographics (M = male, F = female, L = left, R = right).
Brain tumor anatomy for each patient is shown in Fig 1.
Fig 1.
T1-weighted axial MRI slices displaying patient brain tumor anatomy (P01-P18).
Fig 2.
Healthy control group maps (n = 12) for the Hand Squeezing (HS), Rhyming Words (RW), and Phonemic Fluency (PF) tasks.
Peak coordinates are provided in Table 2. Abbreviations: PG, PoG = precentral, postcentral gyrus; SFG, IFG, MiFG, MFG = superior, inferior, middle, medial frontal gyrus; STG, TTG = superior, transverse temporal gyrus. BA = Brodmann area.
Table 2.
Peak Talairach coordinates of activated brain regions for the hand squeezing (HS), rhyming (RW), and phonemic fluency (PF) tasks.
Abbreviations: SFG, IFG, MiFG, MFG = superior, inferior, middle, medial frontal gyrus; STG = superior temporal gyrus.
Fig 3.
Group means (patients and controls), standard error, and single-subject values for the Jaccard index, COM/Peak displacement, and tdiff.
Significant p-values are bold and labelled with an asterisk. Note: 95% confidence intervals are plotted for tdiff.
Fig 4.
Single-subject overlap (red) and union (blue) of active voxels across test sessions.
Patients who produced the highest (left column) and lowest (right column) Jaccard index (Jo) are shown for each functional task in the left and right columns, respectively.
Table 3.
Average reliability metrics and p-values returned from the Wilcoxon rank sum test for comparisons between the patient and control groups.
Significant p-values are bold and labelled with an asterisk (*).
Fig 5.
Test and re-test run correlations of LIe (laterality index characterized by the extent of activated brain volume) in patients (red) and controls (blue) for the rhyming task and phonemic fluency task.
The line of best fit and confidence interval (CI) pertain to the healthy control group (blue).
Table 4.
Reliability metrics for language laterality in controls, HGG patients and LGG patients.
LIe and LIm represent the laterality index characterized by the extent of activated brain volume, and the sum of brain map signal intensity, respectively. The Pearson correlation coefficients, r, are reported with their respective confidence interval (CI) in brackets.
Fig 6.
Group means (high-grade glioma = HGG and low-grade glioma = LGG), standard error, and single-subject values for the Jaccard Index, COM/Peak displacement and tdiff.
Significant p-values are bold and labelled with an asterisk. Note: 95% confidence intervals are plotted for tdiff.
Table 5.
Average reliability metrics and p-values returned from the Wilcoxon rank sum test for comparisons between the HGG and LGG groups.
Significant p-values are bold and labelled with an asterisk (*).
Table 6.
Group means, standard deviations and p-values returned from the Wilcoxon rank sum test for comparisons between the RW, PF, and HS tasks in both patients and controls.
Significant p-values are bold and labelled with an asterisk (*).