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Fig 1.

A flow chart to describe the classification process.

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Fig 2.

Batch effects and their COMBAT adjustment on merging Nelson and Rothman datasets.

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Table 1.

The SR of the optimised feature lists on the NelsonB and Rothman datasets.

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Table 2.

The classification statistics, including SR, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were recorded after the classification of each dataset.

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Table 3.

Upper limit of 95% confidence interval (CI Upper) and lower limit of 95% confidence interval (CI Lower) for SR, sensitivity, specificity, PPV and NPV were recorded after the classification of each dataset.

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Table 3 Expand

Fig 3.

The ROC graph is plotted to show the performance of the binary classifiers.

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Fig 4.

A MDS plot created for Beata dataset to show the distribution of its cases and controls.

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Fig 4 Expand