Fig 1.
Representative sequences of the OsiriX segmentation process of two study participants.
(A) Patient with mild (13%) of pulmonary fibrosis. (B) Patient with severe (41%) pulmonary fibrosis. We have developed the pulmonary fibrosis fraction by the following formula: total HRCT lung volume (−1.024 to −200)–nonfibrotic HRCT lung volume (−1.024 to –700) divided by total HRCT lung volume (−1.024 to −200) multiplied by 100.
Table 1.
Baseline characteristics of the patients.
Table 2.
Comparison among baseline characteristics in SSc patients with diffuse cutaneous disease (n = 55) and limited cutaneous disease (n = 71).
Fig 2.
Scatter plots with regression line.
(A) Correlation between computer-aided method (CaM) system for quantification of ILD on HRCT in SSc and the conventional visual reader-based score (CoVR). (B) Correlation between percentage of pulmonary fibrosis on CaM system and FVC, % predicted. (C) Correlation between percentage of pulmonary fibrosis on CaM system and DLco, % predicted. (D) Correlation between percentage of pulmonary fibrosis on CaM system and HAQ-DI.
Table 3.
Summary of the results of multiple regression analysis, with regression coefficients for the predictor variables on CaM results and CoVR scores.