Table 1.
Classification of detective cytokines and chemokines.
Table 2.
Patient characteristics.
Fig 1.
Representative plasma cytokine/chemokine expression levels in TB patients (n = 151) and no-TB donors (n = 107).
(A) TNF-α, (B) IFN-γ, (C) IP-10/CXCL-10, (D) MIP-1β, and (E) IL-6 levels. *P < 0.05, **P < 0.001. P: P value. Independent-sample T testing was performed to compare the results from TB patients with those of no-TB cases.
Fig 2.
Cytokine/chemokine profiles were established for patients with 3 distinct presentations of TB, for BCG-vaccinated healthy donors (BHD), and for non-TB patients.
The levels of (A) IFN-γ, (B) TNF-α, (C) IL-1β, (D) IL-6, (E) IP-10/CXCL-10, (F) MCP-1, and (G) MIP-1β are shown. *P < 0.05, **P < 0.001. P: P value; ANOVA, analysis of variance. When the variance between samples was equal, least significant difference (LSD) post-hoc tests were performed. Dunnett’s T3 test was used when the variance was not equal.
Table 3.
Association of patient cytokine expression profiles and disease.
Fig 3.
Cytokine/chemokine levels in PBMCs from BCG-vaccinated healthy donors (BHD), with or without ESAT-6 stimulation.
The levels of (A) TNF-α, (B) IL-1β, (C) MIP-1β, (D) GM-CSF, (E) IL-12p40, (F) IL-12p70, (G) IL-10, (H) IL-1α, and (I) CX3CL1 are shown. *P < 0.05, **P < 0.001. P: P value. An independent-sample T test was performed.