Fig 1.
Recruitment and randomization CONSORT diagram.
Fig 2.
FCTpre & FCTpost: food challenge task before and after rTMS. TDpre & TDpost: temporal discounting task before and after rTMS. Collection of main visual analogue scales (VAS) at TP0 (pre-FCT); main VAS & additional VAS at TP1 (post-FCT/pre-rTMS) & TP2 (post-rTMS & FCT); main VAS only at TP3 (end of session) & TP4 (24 hours following). Saliva samples collected at S0 (pre-FCT), S1 (post-FCT/pre-rTMS), S2 (immediately after rTMS), S3 (post-rTMS/post-FCT) and S4 (end of session).
Table 1.
Baseline characteristics (mean ± SD).
Fig 3.
Mean ± SD of core AN symptoms pre-rTMS, post-rTMS, at the end of the session and after 24 hours.
* p < .05 (prior to Bonferroni corrections). This composite core AN symptom outcome was composed of the urge to restrict (0–10), levels of feeling full (0–10) and levels of feeling fat (0–10) VAS and therefore scores can range from 0–30.
Table 2.
Secondary outcomes; mean ± SD within each group across time points.
AN-R: restrictive subtype; AN-BP: binge/purge subtype. Note: the values above are based on 10cm visual analogue scales (VAS). Scales were scored from ‘no urge to restrict/eat/binge eat/be sick or purge’ or ‘not feeling full/fat/hungry at all’ (0) to ‘extremely strong urge to restrict/eat/binge eat/be sick or purge’ or ‘feeling extremely full/fat/calm/hungry’ (10). The mood VAS was scored from ‘feeling extremely low’ (0) to ‘feeling extremely high’ (10) and the calmness VAS was scores from ‘feeling extremely calm’ (0) to ‘feeling extremely tense’ (10).
Fig 4.
Mean + SD area under the curve (AUC) analysis of the temporal discounting (TD) task pre and post real/sham rTMS.
Increased AUC represents reduced TD i.e. less steep TD/more prudent decision making.