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Fig 1.

Schematic diagram of the surgical procedure to achieve mechanical intestinal obstruction.

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Fig 1 Expand

Fig 2.

a. CT image in frontal plane of the pig abdomen. b. CT image in sagittal plane of the pig abdomen. c. CT image in transversal plane of the pig caudal abdomen.

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Fig 2 Expand

Fig 3.

Mean arterial pressure (MAP, mmHg) and cardiac index (CI, L/min.m2) values up to2 hours after stabilization of IAH.

(*) Indicates significant differences between C and MIO groups at the same sampling interval (p < 0.05). (†) Indicates significant differences in MIO between either T3 or T5 compared to T1 (p < 0.05).

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Fig 3 Expand

Fig 4.

Systemic vascular resistance index (SVRI, dynes.sec/cm5.m2)and pulse pressure variation (PPV, %) values up to2 hours after stabilization of IAH.

(*) Indicates significant differences between C and MIO groups at the sampling interval (p < 0.05).

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Fig 4 Expand

Fig 5.

Central venous pressure (CVP, mmHg) values up to 5 hours after IAH stabilization.

(*) Indicates significant differences between the C and MIO groups at the same sampling interval (p < 0.05).

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Fig 5 Expand

Fig 6.

Airway resistance (Raw, cmH2O/L.sec) and pulmonary compliance (Cdyn, ml/cmH2O) values up to 2 hours after IAH stabilization.

(*) Indicates significant differences between the C and MIO groups at the same sampling interval (p < 0.05).

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Fig 6 Expand

Fig 7.

Abdominal perfusion pressure (APP, mmHg) and lactate (Lc, mmol/L) values up to 2 hours after IAH stabilization.

(*) Indicates significant differences between the C and MIO groups at the same sampling interval (p < 0.05). (†) Indicates significant differences in MIO between T5 compared to T1 (p < 0.05).

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Fig 7 Expand

Fig 8.

Peak pressure (Ppeak, cmH2O) and plateau pressure (Pplat, cmH2O) values up to 5 hours after IAH stabilization.

(*) Indicates significant differences between the C and MIO groups at the same sampling interval (p < 0.05). (†) Indicates significant differences in MIO at either T7, T9 or T11 compared to T1 (p < 0.05).

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Fig 8 Expand

Fig 9.

Gastric intramucosal pH (pHi) values up to 5 hours after IAH stabilization.

(*) Indicates significant differences between the C and MIO groups at the same sampling interval (p < 0.05).

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Fig 9 Expand

Table 1.

Cardiorespiratory, biochemical and perfusion parameters obtained in the MIO model until 2 hours.

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Table 1 Expand