Fig 1.
SCANS longitudinal imaging cohort.
All available DTI scans without EPI warping were used in our analyses. Exit event coding: Death = patient passed away; Dementia = patient developed a primary dementia syndrome; Heart implant = patient was unable to do further MR sessions due to a heart implant; ICH = subject met exclusion criteria after intracerebral haemorrhage; Cognition only = patient withdrew from MR sessions but remained in study for cognition; Withdrawal = patient formally withdrew from the study; Loss to follow-up = patient was lost to follow-up; Major stroke = patient met exclusion criteria after major ischaemic stroke; Cardiac arrest = major cognitive impairment related to hypoxia was seen in a patient after a cardiac arrest.
Fig 2.
A. T1-weighted image B. FLAIR image C. Corresponding tissue segmentation map.
Abbreviations: GM = grey matter; NAWM = normal appearing white matter; Lac. = lacune of presumed vascular origin; WMH = white matter hyperintensity.
Fig 3.
A. An axial fractional anisotropy and B. mean diffusivity map (mm2s-1).
Images are from a 78 year old male from the SCANS cohort and representative of DTI-derived maps of symptomatic cerebral small vessel disease patients.
Table 1.
Baseline characteristics of the longitudinal study cohort.
Table 2.
DTI parameter progression values calculated through linear mixed effect models.
Fig 4.
Average DTI histogram distributions of the baseline longitudinal cohort and at 3 year follow-up.
A. Fractional anisotropy. B. Mean diffusivity (mm2s-1). C. Radial diffusivity (mm2s-1). D. Axial diffusivity (mm2s-1).
Table 3.
The minimum sample size estimation per arm required to test treatment effects of various percentages using DTI parameters.