Table 1.
Characteristics including previous ALL treatment and hormone supplementation in 38 ALL survivors divided by gender with no significant difference in treatment modalities between gender.
Fig 1.
Overview of the delineation of the HT.
Overview of the boundaries used to delineate the HT in T1-weighted MRI acquired at 3T according to the procedure established by Gabery et al., 2014 [17]. A-C represent the hypothalamic region in a coronal plane from rostral to caudal direction. The blue dashed lines illustrate how the hypothalamic region was delineated. Landmarks such as the hypothalamic sulcus and the lateral or medial edge of the optical tract represented by orange stars were identified for the delineation. A straight line between these two points was drawn to set the superior/lateral border of the area. The optical tract was excluded in all slides.
Table 2.
Antrophological measurements and peptides in 21 ALL women 34 years after treatment with CRT compared to 18 healthy matched women.
Table 3.
Antrophological measurements and peptides in 17 ALL men 34 years after treatment with CRT compared to 14 healthy matched men.
Fig 2.
Hypothalamic volume in acute lymphoblastic leukemia (ALL) women and ALL men compared to gender matched controls.
Boxplots illustrating the estimated hypothalamic volumes in ALL survivors compared to gender matched controls.
Fig 3.
A. Relationship between leptin/kg fat mass and HT volume in 34 acute lymphoblastic leukemia (ALL) survivors. Spearman correlation coefficients (r) and levels of statistical significance (p) are shown. B. Relationship between HT volume and fat mass in 34 acute lymphoblastic leukemia (ALL) survivors.
Spearman correlation coefficients (r) and levels of statistical significance (p) are shown.
Fig 4.
A. Relationship between serum ghrelin and age at acute lymphoblastic leukemia (ALL) diagnosis in 38 survivors. Spearman correlation coefficients (r) and levels of statistical significance (p) are shown. B. Relationship between serum ghrelin and follow-up time after acute lymphoblastic leukemia (ALL) diagnosis in 38 ALL survivors.
Spearman correlation coefficients (r) and levels of statistical significance (p) are shown.