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Fig 1.

Measurement of the cerebellar vermis height.

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Table 1.

Demographic and baseline characteristics.

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Table 2.

Fetal Cerebellar Vermis Height (mm) according to gestational age.

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Fig 2.

Anderson-Darling tests and the associated diagnostic plots.

Top left, Box plot of the original measurements. Bottom left, Raw p-values associated with the Anderson-Darling test of normality for the original measurements. Top right, Box plot of the log-transformed data. Bottom right, Raw p-values associated with the Anderson-Darling test of normality for the log-transformed data. The sizes of the circles in the bubble plot are proportional to the numbers of samples (n) available during that week.

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Fig 3.

Normal-based mean curve.

95th and 5th centile curves across gestational age.

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Fig 4.

Z score.

Diagnostic plots for the original measurements.

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Fig 5.

Z score.

Diagnostic plots for the log-transformed data.

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Fig 6.

GAMLSS diagnostic plots.

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Fig 7.

Shape-constrained quantile regression (QR).

Estimates for the conditional median and approximate confidence bands (point-wise bands in dark gray, uniform bands in light gray) compared with the standard normal-based fit.

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Fig 8.

Shape-constrained quantile regression (QR).

Estimates for a range of levels of interest and approximate confidence bands (point-wise bands in dark gray, uniform bands in light gray) compared with the standard normal-based fit.

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Table 3.

Reference Table for Fetal Cerebellar Vermis Height (mm): Normal-Based Model.

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Table 4.

Reference Table for Fetal Cerebellar Vermis Height (mm): Piecewise Linear Quantile Regression Model.

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Table 5.

Reference Table for Fetal Cerebellar Vermis Height (mm): GAMLSS Centile Estimates.

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Table 6.

Reference Table for Fetal Cerebellar Vermis Height (mm): Smooth Quantile Regression Model.

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Table 7.

Median Absolute Deviation (mm) for the predictions obtained at different GAs and quantiles by the four methods considered.

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