Table 1.
Clinical baseline data of the included patients.
Abbreviations: m (male); f (female); NSAID (non-steroidal anti-inflammatory drugs); Y (Yes); N (No).
Table 2.
Location of signal alterations in STIR and DWI (here, only the 25 lesions with a relative ADC increase of more than 15% were considered).
Fig 1.
MR images of 12-year old girl with known CRMO.
a) STIR-weighted images show diaphyseal edematous bone marrow involvement, periostal reaction of the left humerus b) axial series showing large and homogenous bony involvement c) signal alteration in DWI b = 800 images d) ADC increase at the corresponding site.
Table 3.
Measured ADC value for lesion, reference regions, the corresponding ratio and location.
Abbreviations: Y (Yes); N (No).
Fig 2.
“At-a-glance” visualisation of Whole-body-DWI.
Intuitive visualisation of Whole-body-DWI with maximum intensity projection MIP in a 12-year-old girl with multifocal CRMO manifestations shows signal alterations on DWI in the left pelvis (Os ilium) and in the right ankle/ distal tibia.
Fig 3.
a) contrast-enhancement of a CRMO-lesion in the right Os ilium on axial T1-TSE FS b) corresponding signal alteration on STIR images c) correlating signal changes on axial DWI b800 d) and high signal intensity on ADC.
Fig 4.
Increased ADC in CRMO-lesions compared to the corresponding reference regions. Since bone marrow cellularity is highly dependent form lesion location and other individual clinical factors, absolute ADC values both in affected and normal bone varied substantially, which made the recommendation of a generalized threshold impossible.