Table 1.
Demographic data of patients with ICP, ACP and controls used in the study.
Table 2.
Association of SNPs with CP (n = 519) and control (n = 1288) subjects.
Table 3.
Association of SNPs with CP in ICP cases (n = 434) and control (n = 1288) subjects.
Table 4.
Association of SNPs with CP in ACP cases (n = 85) and control (n = 1288) subjects.
Fig 1.
Combined risk analysis to determine the effect of increase in number of ‘effective’ risk alleles with risk of CP.
On y-axis OR and 95% CI are plotted, corresponding to number of effective risk alleles on the x-axis. Number in parenthesis on the x-axis indicates Sample size in each category. For every unit increase in the number of effective’ risk allele, the OR is 1.20 and P value 7.30 x 10-08.
Table 5.
Comparison of SNPs at CLDN2 and MORC4 locus in CP cases and controls.
Fig 2.
Combined risk analysis to determine the effect of increase in number of ‘effective’ risk alleles at CLDN2 and MORC4 loci with risk of CP.
On y-axis OR and 95% CI are plotted, corresponding to number of effective risk alleles on the x-axis. Number in parenthesis on the x-axis indicates Sample size in each category. For every unit increase in the number of effective’ risk allele, the OR is 1.18 and P value 1.08 x 10-05.
Table 6.
Gene-Environment interaction of genetic variants with alcohol and smoking in CP.