Table 1.
Number of Athletes and Controls of Each Study Participating in the GAMES Consortium.
Fig 1.
Manhattan Plot of the Association P Values for the CardioMetabochip SNP Differences in Allele Frequencies Between Endurance Athletes and Sedentary Controls in GENATHLETE.
(A) Athletes with VO2max ≥ 75 ml O2/kg/min (N = 315) vs. Controls (N = 320). (B) Elite Athletes with VO2max ≥ 78 ml O2/kg/min (N = 168) vs. Controls (N = 320).
Table 2.
Discovery Phase: Most Significant Associations of CardioMetabochip SNPs and All Endurance Athletes as well as World-Class Athletes versus Controls in the GENATHLETE Cohort.
Fig 2.
Manhattan plot of -log10(p) values against genomic position for association of elite endurance status with markers in 22 autosomes in Japanese.
Red line refers to p = 5x10-6; blue line refers to p = 5x10-5.
Table 3.
Association Results for Markers Chosen for Replication from the Japanese World-Class Endurance Athlete Cohort.
Table 4.
Results for Replication Meta-Analysis and for Individual Cohorts for All Athletes and Controls of European Descent; Results in bold type are for p≤0.05.
Table 5.
Results for Meta-Analysis of World-Class Athletes and Controls of European Descent; Results in bold type are for p≤0.05.
Table 6.
Results for the Replication in Athletes and Controls from Kenya and Ethiopia; Results in bold type are for p ≤0.05.
Table 7.
Results for the Meta-analysis of All Studies of All Athletes and Controls (GENATHLETE, Japan, Australia, Poland, Russia, Spain, Kenya, and Ethiopia); Results in bold type are for p ≤ 0.05.
Table 8.
Results for the Meta-analysis of All Studies of World-class Athletes and Controls (GENATHLETE, Japan, Australia, Poland, Russia, Spain); Results in bold type are for p ≤ 0.05.