Table 1.
Comparison of MET gene amplification measured by ddPCR versus FISH in gDNA of FFPE tissue.
Fig 1.
Measurement of MET copy number in cancer cell lines using ddPCR versus SNP 6.0.
The data is based on a linear regression model that adjusts for SNP 6.0 with intercept. Solid line indicates fitting curve; gray box represents 95% confidence limits; dashed line depicts 95% prediction limits. Each data for MET CN using ddPCR represents two or three merged technical replicate wells with no template control (NTC) as a negative control.
Fig 2.
Distribution of MET CN measured by ddPCR in MET amplification and non-amplification groups by FISH.
P-value was based on t-test assuming difference variances of each group. Each data for MET CN using ddPCR represents two or three merged technical replicate wells with no template control (NTC) as a negative control.
Fig 3.
Measurement of MET copy number in PDX models using ddPCR versus FISH.
The data is based on a linear regression model that adjusts for FISH ratio with intercept. Solid line indicates fitting curve; gray box represents 95% confidence limits; dashed line depicts 95% prediction limits. Each data for MET CN using ddPCR represents two or three merged technical replicate wells with no template control (NTC) as a negative control.