Fig 1.
Flow chart of the KACLiF study.
Abbreviations: HCC, hepatocellular carcinoma; KACLiF, Korean acute-on-chronic liver failure.
Table 1.
Baseline Patients Characteristics at Enrollment.
ACLF was defined by the AARC or CLIF-C.
Fig 2.
Diagram of the total enrolled patients.
(A) acute deterioration with chronic liver disease (enrolled patients) (N = 1470); (B) CLD patients without prior history of decompensation (N = 1021); (C) cirrhotic patients regardless of prior history of decompensation (N = 1352); (D) ACLF development according to the AARC definition (N = 140); (E) ACLF development according to the CLIF-C definition (N = 274); (F) ACLF development according to the AARC and CLIF-C definitions (N = 74). Abbreviations: CLD, chronic liver disease; ACLF, acute-on-chronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium
Fig 3.
Twenty-eight- and 90-day mortality of patients with ACLF.
(A) AARC definition, (B) CLIF-C definition. *One hundred sixty-three patients were lost to follow up. Abbreviations: AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium
Fig 4.
Kaplan-Meier survival curves according to the definition of ACLF.
(A) 28-day survival and (B) 90-day survival. Abbreviations: ACLF, Acute-on-chronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic Liver Failure Consortium.
Fig 5.
Kaplan-Meier survival curves according to the time of ACLF development.
(A) AARC definition, (B) CLIF-C definition. Abbreviations: ACLF, Acute-on-chronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium
Table 2.
Discordant baseline characteristics between patients with ACLF defined by the AARC or CLIF-C.
Fig 6.
Twenty-eight- and 90-day mortality.
(A) According to the presence of cirrhosis (*15 of patients without LC and 148 patients with LC were lost to follow-up) and (B) according to the presence of ACLF (**138 of patients without ACLF and 31 patients with ACLF were lost to follow-up). Abbreviations: LC, liver cirrhosis; ACLF, acute-on-chronic liver failure
Fig 7.
Ninety-day survival curves according to previous acute decompensation.
(A) Without previous AD vs. with previous AD and (B) without previous AD vs. AD more than 1 year prior vs. AD within 1 year. Abbreviation: AD, acute decompensation
Fig 8.
Kaplan-Meier survival curves of ACLF according to the definition of organ failure (liver failure as a prerequisite vs. extra-hepatic organ failure).
(A) 28-day and (B) 90-day survival according to liver failure as defined by the AARC definition, (C) 28-day and (D) 90-day survival according to bilirubin level. Abbreviations: ACLF, acute-on-chronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium