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Fig 1.

Consort diagram.

NTG indicates normal tension glaucoma; IOP, intraocular pressure; OPP, ocular perfusion pressure; DTFC, dorzolamide/timolol fixed combination.

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Fig 1 Expand

Table 1.

Baseline demographics and clinical characteristics of the study population.

VF = visual field; RNFL = retinal nerve fiber layer.

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Table 1 Expand

Fig 2.

Mean intraocular pressure during the circadian curve for the three crossover phases: at baseline, after dorzolamide/timolol, and after latanoprost.

Vertical bars indicate the 95% confidence interval of the estimates.

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Fig 2 Expand

Table 2.

Intraocular pressure diurnal profiles of two groups.

DTFC = dorzolamide-timolol fixed combination

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Table 2 Expand

Fig 3.

Mean systolic and diastolic blood pressure (BP) during the circadian curve for the three crossover phases: at baseline, after dorzolamide/timolol, and after latanoprost.

Vertical bars indicate the 95% confidence interval of the estimates.

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Fig 3 Expand

Fig 4.

Mean ocular perfusion pressure and diastolic ocular perfusion pressure during the circadian curve for the three crossover phases: at baseline, after dorzolamide/timolol, and after latanoprost.

Vertical bars indicate the 95% confidence interval of the estimates.

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Fig 4 Expand

Table 3.

Systolic BP and diastolic BP diurnal profiles of two groups.

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Table 3 Expand

Table 4.

Heart rate diurnal profiles of two groups.

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Table 4 Expand

Table 5.

Ocular perfusion pressure diurnal profiles of two groups.

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Table 5 Expand

Table 6.

Diastolic ocular perfusion pressure diurnal profiles of two groups.

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Table 6 Expand

Table 7.

Number (%) of Patients with Ocular Treatment-Related Adverse Events.

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Table 7 Expand