Fig 1.
Schematic representations of the RD (panel A) and TLK (panel B) models.
In the RD model, radiation (with dose rate R) produces three DSB classes (DSB1, DSB2, DSB3) with yields (per unit dose) of k1, k2 and k3, respectively. DSB1 and DSB2are rejoined with rates v1 and v2, respectively; DSB3 are unrejoinable. Radiation converts DSB1 to DSB2 and DSB2 to DSB3 with rates proportional to parameters q1 and q2, respectively. In the TLK model, radiation also produces three DSB classes with yields (per unit dose) of c1, c2 and c3, respectively; DSB1 and DSB2 are rejoined with rates λ1 and λ2, respectively; DSB3 are unrejoinable.DSB1 and DSB2are “fixed” to become DSB3with rates ε1 and ε2, respectively. DSB1 interact with each other (by quadratic mis-rejoining) with rate η1, and DSB2 interact with each other with rate η2. DSB1 interact with DSB2 with rate η1,2. Details are described in the main text.
Fig 2.
Dose dependence of best-fit model predictions (curves) for 30 MeV electron data (symbols).
Solid lines = RD model, dashed lines = TLK model. The legend indicates times after HDR single-dose irradiation when DSBs were measured. In this and the following figures, the left-most panels compare both models, the middle panels show the RD model only, and the right-most panels show the TLK model only.
Fig 3.
Time dependence of best-fit model predictions (curves) for 30 MeV electron data (symbols).
Solid lines = RD model, dashed lines = TLK model. The legend indicates radiation doses (HDR, single-dose).
Fig 4.
Time dependence of best-fit model predictions (curves) for LDR γ-ray data (symbols).
Solid lines = RD model, dashed lines = TLK model. The legend indicates radiation doses.
Fig 5.
Dose dependence of best-fit model predictions (curves) for α-particle data (symbols).
Solid lines = RD model, dashed lines = TLK model. The legend indicates times after HDR single-dose irradiation when DSBs were measured.
Table 1.
Information theoretic performance assessment (by ΔAICc) and best-fit parameter values for the RD and TLK models.
ΔAICc = 0 suggests the strongest support from the data for the given model among all tested models, whereas ΔAICc > 6 suggests poor support. Parameter meanings are provided in the caption to Fig 1 and in the main text.
Table 2.
GOF assessment for the RD and TLK models.
R2 = coefficient of determination. The intercept (i) and slope (s) of linear regression of model predictions vs. observed data point values were used to assess GOF. Systematic deviations of predictions from the data (marked in bold font) are suggested if the 95% CIs (shown in parentheses) of the intercept do not include zero and/or if the 95% CIs of the slope do not include unity.
Fig 6.
Dose rate dependence of best-fit model predictions for sparsely-ionizing radiation.
Solid lines = RD model, dashed lines = TLK model. The legend indicates radiation doses.