Fig 1.
Enhanced depth imaging (EDI) scan from spectral domain optical coherence tomography (SD OCT) with semiautomated software image segmentation of the choroid representing retinal pigment epithelium (RPE) and choroid scleral junction as the boundary for choroidal area.
Definitions of Areas on EDI-OCT: Subfoveal choroidal thickness (SFCT): Distance between the outer border of hyperreflective retinal pigment epithelium (RPE) and the outer border of the choroid beneath the centre of the fovea. Luminal Area (LA): Area of dark pixels in the choroid seen on binarised EDI-OCT images was defined as LA or vascular area. This area corresponds to the vascular area of the choroid when compared to original EDI-OCT images. Stromal Area (SA): Area of light pixels in the choroid seen on binarised EDI-OCT images was defined as SA or interstitial area. This area corresponds to the interstitial areas of the choroid when compared to original EDI-OCT images. Choroidal Vascularity Index (CVI): The ratio or proportion of the LA within the circumscribed subfoveal choroidal area.
Fig 2.
Choroidal enhanced depth imaging (EDI) SD OCT scans showing black areas (luminal areas, LA) (2A and 2C) and white areas as interstitial areas (stromal area, SA) (2A and 2C).
The areas are seen more clearly after image segmentation using semiautomated software (2B and 2D).
Fig 3.
A schematic illustration of the EDI SD OCT scan with superimposed binarized image showing segmentation of the choroidal structures.
Table 1.
Retinal, retinal pigment epithelium (RPE) and choroidal thickness and intensity measurement for uveitic eyes using OCTOR software at baseline and presentation.
Fig 4.
4A: Scatter plot representing the total subfoveal choroidal area (TCA) for uveitic eyes and control eyes at baseline and 3 month follow up. 4B: Scatter plot representing the luminal area (LA) for uveitic eyes and control eyes at baseline and 3 month follow up. 4C: Scatter plot representing the stromal area (SA) for uveitic eyes and control eyes at baseline and 3 month follow up. 4D: Scatter representing the choroidal vascularity index (CVI) for study (uveitic) eyes and control eyes at baseline and 3 month follow up.
Fig 5.
Composite box plots representing the baseline and follow up measurements for total choroidal area (TCA) (A), luminal area (LA) (B), stromal area (SA) (C) and choroidal vascularity index (CVI) (D) for both control and uveitic (study) eyes.
Table 2.
Image binarization indices for both study and control eyes at baseline and at three months follow up.