Table 1.
Demographic and clinical features of patient cohorts and controls.
Fig 1.
Proportion of CD3+CD4+IL-17A Th17 cells in atypical ON, typical ON and HCs.
Lymphocyte (A), CD3+CD4+ T Cells (B), and Isotype control staining of IL-17A (C) in a representative subject. Th17 cells from representative patients with atypical ON (D) or typical ON (E), and from a healthy control subject (F). Note that the proportion of Th17 cells is highest in the atypical ON patient (D), intermediate in the typical ON patient (E) and lowest in the control subject (F).
Fig 2.
A. The percentage of CD3+CD4+IL-17A+ Th17 cells in patients with atypical ON (left) or typical ON (middle), and from control subjects (right). The percentage of Th17 cells was higher in atypical ON patients than in typical ON patients (P<0.01) and controls (P<0.01). The percentage of Th17 cells in patients with typical ON was significantly higher than in control subjects (P<0.01). B. The percentage of CD4+CD25+FoxP3+ Treg cells in patients with atypical ON (left) or typical ON (middle), and from control subjects (right). The percentage of Treg cells was significantly lower in atypical ON patients or patients with typical ON than in controls (both P<0.01). The number of Treg cells did not statistically differ between patients with typical ON compared to atypical ON patients (P>0.05).C. The ratio of Th17/Treg lymphocytes in patients with atypical ON (left) or typical ON (middle), and from control subjects (right).
Atypical ON patients had significantly lower ratios of Treg/Th17 than patients with typical ON (P<0.01). The Treg/Th17 ratio was significantly lower in both patient groups than in control subjects (P<0.01 for both comparisons).
Fig 3.
Proportion of CD4+CD25+FoxP3+ Treg cells in atypical ON, typical ON and controls.
Lymphocyte (A), CD4+ T Cells (B), Isotype control staining of CD25 and FoxP3 (C), in a representative subject. Treg cells from representative patients with atypical ON (D) or typical ON (E), and from a healthy control subject (F). Note that the proportion of Treg cells is lowest in the atypical ON patient (D), intermediate in the typical ON patient (E) and highest in the control subject (F).