Fig 1.
Flow chart depicting the selection process of studies included in the meta-analysis.
Table 1.
Main Characteristics of Studies Included in the Meta-analysis.
Table 2.
Quality Appraisal of Observational Studies.
Fig 2.
Risk ratios of all-cause mortality rates: high versus low AUC0-24/MIC ratio.
Test of all-cause mortality rates for overall effect: Z = 3.72, P<0.001; test of all-cause mortality rates in Etest Study subgroup for overall effect: Z = 2.12, P = 0.034; test of all-cause mortality rates in BMD Study subgroup for overall effect: Z = 3.12, P = 0.002.
Fig 3.
Risk ratios of rates of infection treatment failure: high versus low AUC0-24/MIC ratio.
Test of rates of infection treatment failure for overall effect: Z = 3.34, P = 0.001.
Table 3.
Outcomes, breakpoints of AUC0-24/MIC ratio and MIC determination methods of studies included in the meta-analysis.
Fig 4.
Risk ratios of rates of infection treatment failure: high versus low AUC0-24/MIC ratio (Kullar’s study was excluded).
Test of rates of infection treatment failure for overall effect: Z = 5.55, P<0.001.