Table 1.
Baseline Characteristics of 260 Japanese AIH Type 1 Patients.
Table 2.
Baseline characteristics of AIH patients with or without anti-gAChR Ab (alpha 3).
Table 3.
Baseline characteristics of AIH patients with or without anti-gAChR Ab (beta 4).
Fig 1.
A) LIPS for gAChR in the sera from patients with autoimmune hepatitis (AIH) and controls. We tested the sera from patients with AIH, disease controls (ODC), and healthy controls (HC). a) Anti-gAChRα3 antibodies were detected in 28 samples. The mean anti-gAChRα3 antibody level in the HC was 0.305 antibody index (A.I.), which was significantly lower than in the AIH samples with a mean level of 0.609 A.I. (p < 0.001). B) Anti-gAChRβ4 antibodies were also detected in patient with AIH. The mean anti-gAChRβ4 antibody levels in the HC was 0.367 A.I., which was significantly lower than the mean levels of 0.506 A.I. in the AIH samples (p < 0.001).
Fig 2.
Relationship between anti-gAChR α3 and anti- gAChR β4 antibody levels.
Calculation of the correlation between anti-gAChR α3 and anti-gAChR β4 antibody levels in AIH patients with both autoantibodies (n = 17). Correlation was calculated using Spearman’s Rank Correlation test. There is no correlation at all (r = -0.04, p = 0.58).
Table 4.
HLA-DRB1 alleles of AIH patients with or without anti-gAChR Ab (alpha 3).
Table 5.
HLA-DRB1 alleles of AIH patients with or without anti-gAChR Ab (beta 4).
Table 6.
HLA-DRB1 alleles of AIH patients with or without anti-gAChR Ab (beta 4).
Table 7.
HLA-DRB1 carrier status in patients with AIH and Healthy controls.
Fig 3.
LIPS for gAChR in the sera from AIH patients with or without HLA-DRB1 *0403 allele.
We tested the sera from AIH patients with or without HLA-DRB1 *0403 allele. The mean anti-gAChR α3 antibody level in patient with *0403 allele was 1.06 antibody index (AI), which was significantly higher than in those without *0403 allele with a mean level of 0.59 A.I. (p = 0.043). The mean anti-gAChR β4 antibody level in patients with *0403 allele was 0.76A.I, which was significantly higher than in the mean level of 0.50A.I. in those without *0403 allele (p = 0.010).
Table 8.
HLA-DQB1 alleles of AIH patients with or without anti-gAChR Ab.