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Fig 1.

Schematic Markov states.

Health states include: exacerbation-free, exacerbation states: exacerbation requiring oral corticosteroids, emergency room visit, hospitalizations, and death state.

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Table 1.

Model Parameters.

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Table 2.

The expected value and 95% CrI of outcomes over a five year time frame.

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Table 2 Expand

Fig 2.

(A) Cost-effectiveness plane; (B) Cost-effectiveness acceptability curve; and (C) Expected value of information.

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Fig 2 Expand

Fig 3.

One-way sensitivity analysis: (A) BT versus standard therapy, (B) omalizumab versus BT.

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Fig 4.

Sensitivity analysis for the costs of BT.

Incremental cost-effectiveness ratio as a function of BT’s cost: (A) BT versus standard therapy, (B) omalizumab versus BT.

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Fig 4 Expand