Table 1.
Flucon = fluconazole, itracon = itraconazole, amph sus = amphotericin suspension (10 mg/ml swirl and swallow 4x daily). All swabs were taken for routine Dg purposes. Ethical approval was obtained under the Newcastle Autoimmune Inflammatory Rheumatic Disease Research Biobank (NAIRB) Ref No NAIRB-DL-01 dx obtained from the Southwest 3 Research Ethics Committee (Ref. 10/H0106/30) to perform research on samples collected as part of the NAIRB by researchers based at Newcastle University. Pts 1–5 had primary CMC; whole exome sequencing confirmed gain-of-function STAT1 mutations in 3 while no mutation was identified in 2 patients; P4 had candida granuloma of soft palate. P6 had 2oCMC due to steroid inhalers (asthma). Swabs were processed in the Department of Microbiology, Newcastle upon Tyne Hospitals NHS Trust (NUTH): Mohammad Raza, Consultant Microbiologist (Muhammad.Raza@nuth.nhs.uk) and Claire Rennison, Senior BMS (now retired).
Table 2.
MLST DSTs for 42 C. albicans isolates from 6 CMC patients and their antifungal susceptibilities.
Fig 1.
Multiple sequence alignment of concatenated SNPS of DSTs from 6 CMC patients.
Multiple sequence alignment of C. albicans MLST concatenated SNPs for the 6 DSTs. Blue and green colours are homozygous SNPs, yellow, orange, red, pink and brown are heterozygous SNPs, the boundaries of the 7 sequenced regions are indicated at the x axis. SplitsTree phylogram of the DSTs profiles appears at the y axis.
Fig 2.
Normalised frequency distribution (NFD) of 6 comparator datasets.
NFD heat-map of frequency differences for six datasets (B-G) normalised against a non-redundant dataset of 2867 isolates curated at the central C. albicans database (Dataset A).