Table 1.
Descriptive statistics (mean ± standard deviation) of GOLDN and Bogalusa Heart Study participants with and without MetS.
Fig 1.
Epigenome-wide association Manhattan plot for MetS in the GOLDN dataset (n = 846). MetS; metabolic syndrome.
The blue line indicates a marginal significance level of 1.0 x 10−5; the red line indicates the genome-wide significance level of 1.1 x 10−7.
Fig 2.
Differences in mean DNA methylation (%) of cg00574958 in CPT1A by risk factors of MetS.
X-axis shows the criteria met (yes/no) for each component of MetS; Y-axis the mean DNA methylation (%) with error bars showing standard error. *P < 0.01, **P < 0.001. Black bars, MetS criteria not met; gray bars, MetS criteria met. MetS criteria include the following: waist circumference ≥ 102 cm for men and ≥ 88 cm for women; high-density lipoprotein cholesterol < 40 mg/dL for men and < 50 mg/dL for women; triglycerides ≥ 150 mg/dL; blood pressure (systolic/diastolic) ≥ 130 / ≥85 mm Hg; and fasting blood glucose ≥ 100 mg/dL.
Table 2.
Association of top two CpGs for MetS in GOLDN discovery and replication in BHS.