Table 1.
Information about the scanners, scanning parameters, and reconstructions parameters of the scanners used in this study.
Fig 1.
Example of registered NCCT (left column) and CTA (right column) images of a patient suffering from an M1 occlusion (white arrows).
The green overlay (on the left) represents the manually measured density using the three spherical ROI. On the right panel, the red overlay highlights the result of the automated thrombus segmentation on CTA.
Fig 2.
Histograms of density distribution of six automatically segmented entire thrombi.
The colored vertical lines indicate the observer density measurements (blue for observer 1, red for observer 2 and green for observer 3). The purple curve represents the fitted normal curve.
Table 2.
Descriptive statistics of the assessment of entire thrombus and the manual density measurements.
Fig 3.
Density distributions of a randomly selected set of 30 patients and corresponding manual measurements.
The boxplots represent the first to third quartile the density distribution of the entire thrombus segmentation. The vertical lines indicate the variability outside the Q1 and Q3. The colored circles indicate the observer density measurements (blue for observer 1, red for observer 2 and green for observer 3).
Fig 4.
Bland-Altman graph assessing the Interobserver agreements of Observer 2 and Observer 3 with the reference Observer 1.
The colors indicate pairs of observers (blue for observer 1 and observer 2, and green for observer 1 and observer 3). The color dotted lines represent the limits of agreements; the solid line represents the mean paired difference.
Fig 5.
Scatter plot of the manual thrombus density measurement compared to the thrombus measured of the entire thrombus (A), Scatter plot of the manual thrombus density measurement compared to the thrombus volume(B). Scatter plot of the manual thrombus density measurement compared to the thrombus density IQR (C).
The colors indicate the different observers (blue for observer 1, red for observer 2, and green for observer 3).
Table 3.
Results of statistical analyses relating manual thrombus density measurements and median value of the entire thrombus measurements with the heterogeneity of the thrombus, as expressed by the inter-quartile range (IQR) of the entire thrombus measurement and with the thrombus volume in mm3.