Table 1.
Clinical characteristics of study participants.
Table 2.
Characteristics of 4 SNPs in MTHFR gene.
Table 3.
Allelic and genotypic associations of 4 SNPs with ARC risk in our case-control study.
Table 4.
Associations of SNPs rs1801133 and rs9651118 with the risk of ARC subtypes.
Table 5.
Associations of haplotypes in MTHFR gene with ARC risk.
Table 6.
Joint effect of SNP rs1801133 and rs9651118 on ARC risk.
Table 7.
MTHFR activity and tHcy levels with respect to different genotypes of SNP rs1801133 and No. of unfavorable genotypes in our population.
Fig 1.
Associations of SNP rs1801133 and No. of unfavorable genotypes with the plasma MTHFR activity and tHcy levels in healthy controls and patients with cortical ARC.
(A) Associations of SNP rs1801133 with MTHFR activity, (B) Associations of No. of unfavorable genotypes with MTHFR activity, (C) Associations of SNP rs1801133 with tHcy levels, (D) Associations of No. of unfavorable genotypes with tHcy levels. ANCOVA models were used to assess statistical significance. In Fig 1 (A) and (C), associations of SNP rs1801133 with the plasma MTHFR activity and tHcy levels were calculated based on an additive model.