Table 1.
Hematological parameters and genotypes of Vietnamese and Laotian subjects with Hb CS (n = 130).
Data are presented as mean ± standard deviation or as raw data where appropriate. Nd: not determined.
Fig 1.
α-Globin gene haplotypes associated with Hb CS genes in Vietnamese and Lao subjects as compared to those described in other populations.
Number of alleles detected in each haplotype is indicated. Plus and minus indicate the presence and absence of each polymorphic site. nd: not determined.
Fig 2.
Map of Southeast Asia and China demonstrating distribution of the two major haplotypes associated with Hb CS alleles in the region.
Fig 3.
Phylogenetic tree of the Hb CS associated haplotypes constructed using the DendroUPGMA software applying Jaccard (Tanimoto) coefficient with default settings and 100 bootstrap replicates.
Numbers indicate the branch lengths (divergence). Two major Asian Hb CS haplotypes; (+—M + + -) and (+—S + + -) and the predicted Mediterranean haplotype (-—L +—-) are indicated in bold face. The major haplotypes, (+—M + + -) and (+—S + + -), of Hb CS in Asian populations show common ancestors and are separated into each branch. In contrast, the Mediterranean haplotype represents clearly different origin.