Fig 1.
Flowchart for the collection and classification of patient samples in the study.
The blood samples were collected from suspected influenza inpatients at INER from 2009–2012. Abbreviations: ILI: influenza-like illness; RT-PCR: real-time PCR.
Table 1.
Characteristics of the patients at hospital admission.
Table 2.
Differences in clinical parameters of severity among patients with confirmed influenza pA/H1N1 vs. ILI.
Table 3.
Genotype frequencies and associations with susceptibility and risk of severe influenza A (H1N1) infection.
Fig 2.
Haplotype for TNF gene at Chr 6 in ILI patients.
Linkage disequilibrium between the four single nucleotide polymorphisms identified at chromosome 6 in the TNF gene (generated for the ILI patients in Haploview 4.2).
Table 4.
Genotypes associated with clinical severity variables in patients with influenza A (H1N1) pdm09.
Fig 3.
Concentrations of IL-6, IL-5, and GM-SCF in p AH1N1, ILI patients and AHC at admission.
Box and whisker plots of cytokine levels in sera from the AHC, ILI, and pA/H1N1 groups. Boxes represents the 25–75 quartile, the whiskers represent the range of values, the middle line inside the box is the median, and the outlier values are represented as circles outside the boxes. The p-values (** and * representing <0.001 and <0.05, respectively) were calculated by one-way ANOVA and are presented above the graphs.