Fig 1.
Enrollment and Study Participation.
PCV10 indicates 10-valent pneumococcal conjugate vaccine, Synflorix; PCV13 indicates 13-valent pneumococcal conjugate vaccine, Prevenar-13. * When the enrolment target was reached, further children were considered redundant, and their parents’ informed consent procedures were cancelled. ** Plasma cell and memory B-cell analysis published by van Westen et al.[27].
Table 1.
Characteristics of the participants.
Fig 2.
Pneumococcal serotype-specific measurements.
IgG geometric mean concentrations (GMCs) pre-booster, one week post-booster and one month post-booster; Mean avidity indices of IgG antibodies pre-booster, one week post-booster, and one month post-booster; opsonophagocytosis geometric mean titers (GMTs) pre-booster and one week post-booster. *indicates significant differences (<0.05), higher in the PCV10 group than the PCV13 group #indicates significant differences (<0.05), higher in the PCV13 group than the PCV10 group **sample size for opsonophagocytosis assays: PCV10 group N = 22–27, PCV13 group N = 25–31
Table 2.
Seroprotection rate of the antibody concentrations against 13 pneumococcal serotypes for the PCV10 group and the PCV13 group with p-values for differences between the groups.
Table 3.
Seroprotection rate (%) for diphtheria, tetanus, pertussis, and Hib antigens for the PCV10 group and the PCV13 group with p-values for differences between the groups.