Table 1.
Age (years), EDSS, disease duration (years), gender and MS-type statistics for the 40 patients in this study.
Fig 1.
Example of ROI volumes overlaid on T1w images before and after setting a T1-RT threshold.
A: Axial slice of the cerebrum with multiple T1 hypointense lesions. B: Manually placed ROIs without applied threshold: BHvis (red), CE lesion (green). C: Remaining ROIs after applying the obtained optimal threshold of T1-RT >1500 ms with highest correlation to EDDS; CE lesions were not affected by thresholds.
Table 2.
Mean number, volume and T1-RT for different lesion classifications and cortex.
Fig 2.
Box Plots showing T1-RT distribution in different lesion types.
T1-RT = T1 relaxation time; total-FLAIR lesions = lesions from the semi-automatically segmented FLAIR lesions masks; pure-FLAIR lesions = lesions from the semi-automatically segmented FLAIR lesions masks that did not correspond to a BHvis or CE lesion; BHvis = manually segmented black holes without applied threshold, BHsthr1500 = manually segmented black holes with T1-RT higher than 1500 ms.
Table 3.
Spearman rank correlations coefficients for lesion volume and EDSS at different T1-RT thresholds.
T1-TR thresholds in ms, BHthr volume = mean cumulative BHthr volume per patient in mm3, total-FLAIRthr lesion volume = mean cumulative total-FLAIRthr lesion volume per patient in mm3, Spearman r = Spearman rank coefficients for lesion volume and EDSS.
Fig 3.
Spearman rank correlation coefficients for lesion volume and EDSS at different T1-RT thresholds.
▲ = BHsthr volume vs. EDSS, ◙ = total-FLAIRthr lesion volume vs. EDSS (black symbols indicate a significant correlation). T1-RT = T1 relaxation time.
Table 4.
Spearman rank correlations coefficients for lesion volume and MSFC at different T1-RT thresholds.
T1-TR thresholds in ms, BHthr volume = mean cumulative BHthr volume per patient in mm3, total-FLAIRthr lesion volume = mean cumulative total-FLAIRthr lesion volume per patient in mm3, Spearman r = Spearman rank coefficients for lesion volume and EDSS.
Fig 4.
Spearman rank correlation coefficients for lesion volume and MSFC at different T1-RT thresholds.
▲ = BHsthr volume vs. MSFC, ◙ = total-FLAIRthr lesion volume vs. MSFC (black symbols indicate a significant correlation). T1-RT = T1 relaxation time.