Fig 1.
Macroscopic aspect of a hypertrophic scar in a nude mouse.
A. Characteristic stiffness of a human hypertrophic scars after 35 days. B. After sacrificing the animal, vessels can be seen coming from the surrounding tissue arrived to nourish the hypertrophic scar.
Table 1.
Morphological variables of the hypertrophic scars.
Comparison between the groups using Kruskall-Wallis test.
Table 2.
Statistical results in the comparison between subgroups.
Fig 2.
Box plots representing values corresponding to total area of the three groups. (cm2).
Fig 3.
Box plot corresponding to collagen fibers area of the three groups (cm2).
Fig 4.
Box plot corresponding to thickness of scars in three groups (cm).
Fig 5.
Histological preparations of hypertrophic scars staining with Masson’s Trichrome. (20x magnification).
Fig 6.
Images of hypertrophic scars staining with anti-collagen I.
A (basal), B (placebo) and C (treatment) belong to the same scar. D (basal), E (placebo) and F (treatment) are from a second scar. Fewer stained fibers can be seen in C and F when comparing with the other groups.
Fig 7.
Images of hypertrophic scars staining with anti-collagen III.
A (Basal), B (placebo) and C (treatment) represent the same scar. Differences between these three groups is minimal. Images from a second scar, D (basal), E (placebo) and F (treatment).
Fig 8.
Images of hypertrophic scars staining with anti-fibrillin-1.
A (basal), B (placebo) and C (treatment) belong to the same scar and D (basal), E (placebo) and F (treatment) to a second one. It is noticeable that there is almost a complete absence of elastic fibers in A and D (basal group). Rearrangement of elastic fibers system is more obvious in pictures C and F.
Table 3.
Comparison between the groups of collagen I, collagen III, Fibrillin-1 and ratio Collagen I/ Collagen III.
Table 4.
Statistical results in the comparison between subgroups.