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Table 1.

Software used in this study.

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Fig 1.

Mimics Graphical User Interface (GUI).

In green the result of the segmentation with “Dynamic region growing” in MBM. A coronal, B axial, C sagittal view of the CT data and D the 3D model of the airway.

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Fig 2.

The figure shows a detail of segmentation in MPM.

The leakage is well visible at the end of the branches as “clouds” around the branch. The user can select manually the leakage that has to be removed (red segment) and put the leakage marker in its place (purple ball).

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Fig 3.

OsiriX GUI.

A) axial view of the original CT data, 2D result of the segmentation with threshold upper/lower algorithm, window of the region growing with threshold (upper/lower) algorithm; B) 3D panel.

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Fig 4.

CustusX GUI for TSF.

axial, coronal, sagittal view (right side), 3D model of the airway with centerline (center) and configuration filter parameters (left side).

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Fig 5.

The figure shows a flowchart of analysis of CT data.

In OsiriX, MBM, MPM and CustusX.

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Fig 6.

Labeling in Mimics.

The figure shows the centerline labeling in MPM. fig B display centerline extracted and fig B list labelling with Mimics.

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Table 2.

Number of clicks, mean ± standard deviation needed to import data and, perform a segmentation and centerlines extraction.

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Fig 7.

The figure shows segmentation, centerline, model and a detail of the airways of patient #1 in MBM (A,B,C), MPM (D,E,F), TSF(G,H,I) (CustusX) and OsiriX(J,K,L) respectively (left to right).

The centerline for Osirix was produced in CustusX by using the standard filter for centerline extraction (thinning algorithm). In the centerline of OsiriX there are three black circles caused by holes in the segmentation.

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Table 3.

Method comparison, number of branches in each generation for all patients.

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Fig 8.

Number of patients in each generation.

The plot shows the number of patients that each software is able to detect, up to the sixth generation.

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Fig 9.

Average branches detected in each generation.

The plot shows the mean and standard deviation of number of branches per generation for each method.

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Table 4.

Reference segmentation results, comparison for MPM and TSF method, one can compare to results in EXACT09 webpage (http://image.diku.dk/exact/).

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Table 5.

Advantages and disadvantages between Mimics (Basic and Pulmonology module), CustusX and OsiriX.

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