Fig 1.
Four-set Venn diagram of the overlap of significantly differentially expressed genes (SDEGs) in GSE28146 gene expression datasets.
Courtesy: Oliveros, J.C. (2007–2015) Venny. An interactive tool for comparing lists with Venn's diagrams. Publicly available at http://bioinfogp.cnb.csic.es/tools/venny/index.html.
Fig 2.
Alzheimer’s disease direct interaction network.
The 15 genes/proteins implicated in AD pathology are highlighted in green and the two genes/proteins of potential interest for that disease are highlighted in blue.
Table 1.
Summary of genes of interest and genes already known in Alzheimer's disease.
Fig 3.
Alzheimer’s disease compact shortest path network.
The genes/proteins implicated in AD pathology are highlighted in green and red. The genes/proteins of potential interest are highlighted in blue and orange. (see Table 1 for gene highlighting details).
Table 2.
Genes of interest for Alzheimer’s disease identified by “guilt-by-association” with the known AD-related genes.
Table 3.
Gene set DAVID enrichment analysis of Alzheimer’s disease compact shortest-path network.
Table 4.
Enriched KEGG pathways in Alzheimer’s disease resulted from DAVID analysis.
Fig 4.
Integrated Alzheimer’s disease mechanism network.
The 37 genes/proteins are found in common in all 12 enriched KEGG pathways. Genes/proteins implicated in AD pathology are highlighted in green/red and the genes/proteins of potential interest are highlighted in blue/orange (See Table 1. for details). Genes/proteins causing neuronal loss are highlighted in purple and those that help in neuronal survival are in yellow.
Fig 5.
MicroRNA incorporated integrated Alzheimer’s disease mechanism.
The 37 genes/proteins found in common in all 12 enriched KEGG pathways are regulated by 22 microRNAs. Genes/proteins implicated in AD pathology are highlighted in green/red and the genes/proteins of potential interest are highlighted in blue/orange (See Table 1) for details. Genes/proteins causing neuronal loss are highlighted in purple and those that help in neuronal survival are in yellow.
Fig 6.
Alzheimer’s disease miRNA regulatory network.
The genes/proteins and miRNAs implicated in AD pathology are highlighted in green and the genes/proteins of potential interest are highlighted in blue. Genes/proteins that code for transcription factors (TFs) are highlighted in yellow.