Table 1.
Clinical demographics of study population.
Abbreviations: BMI, body mass index; HDL-C, high density lipoprotein-cholesterol; HOMA-B, the homeostasis model assessment for β-cell function; HOMA-IR, the homeostasis model assessment for insulin resistance; ISIm, Matsuda index; MetS, metabolic syndrome; OGTT, oral glucose tolerance test; T2D, type 2 diabetes. Data are shown as median (interquartile range) or %. All non-Gaussian distributed quantitative traits were natural logarithmically transformed to normalize distributions. P values were calculated to assess the intergroup differences using χ2 test or one-way ANOVA.
Table 2.
Associations between T2D-related SNPs with MetS-related components in T2D participants.
Abbreviations: BMI, body mass index; Chr, chromosome; CI, confidence interval; HDL-C, high density lipoprotein-cholesterol; MetS, metabolic syndrome; OR, odds ratio; SNP, single nucleotide polymorphism; T2D, type 2 diabetes. OR and 95% CI are indicated for the reported T2D risk allele of each SNP with MetS or MetS-related components using logistic regression under an additive assumption using the following models: model 1, age and sex were adjusted as co-variables; and model 2, age, sex, and BMI were adjusted. Associations with P value < 0.05 are shown in bold and underlined.
Table 3.
Association between T2D GRS and the risk for abdominal obesity in T2D patients.
Abbreviations: BMI, body mass index; CI, confidence interval; GRS, genotype risk score; OR, odds ratio; Q, quartile; T2D, type 2 diabetes; WC, waist circumference. OR and 95% CI are reported for T2D GRS quartiles with the risk for abdominal obesity using logistic regression under an additive assumption using the following models: model 1, age and sex were adjusted as co-variables; model 2, age, sex, and BMI were adjusted. P values are calculated for T2D GRS quartiles. Ptrend values are calculated for T2D GRS. All non-Gaussian distributed quantitative traits were natural logarithmically transformed to normalize distributions. Associations with P values < 0.05 are shown in bold and underlined.
Table 4.
Associations between T2D-related SNPs with non-MetS T2D and MetS T2D compared to non-MetS controls in DMS.
Abbreviations: BMI, body mass index; Chr, chromosome; CI, confidence interval; DMS, Chinese National Diabetes and Metabolic Disorders Study; MetS, metabolic syndrome; OR, odds ratio; SNP, single nucleotide polymorphism; T2D, type 2 diabetes. OR and 95% CI are indicated for the reported T2D risk allele of each SNP using logistic regression under an additive assumption using the following models: model 1, age and sex were adjusted as co-variables; and model 2, age, sex, and BMI were adjusted. Associations with P values < 0.05 are shown in bold and underlined.
Table 5.
Associations between T2D-related SNPs with T2D combined with each MetS-related component compared with non-MetS super controls in DMS.
Abbreviations: BMI, body mass index; Chr, chromosome; CI, confidence interval; DMS, Chinese National Diabetes and Metabolic Disorders Study; HDL-C, high density lipoprotein-cholesterol; MetS, metabolic syndrome; OR, odds ratio; SNP, single nucleotide polymorphism; T2D, type 2 diabetes. OR and 95% CI are indicated for the reported T2D risk allele of each SNP using logistic regression under an additive assumption using the following models: model 1, age and sex were adjusted as co-variables; model 2, age, sex, and BMI were adjusted. Associations with P values < 0.05 are shown in bold and underlined.