Table 1.
General characteristics of CIS-MS, CIS-nonMS, NIND and IND groups.
Fig 1.
Receiver operator curve (ROC) characteristic analysis between CIS-MS and control group.
AUC: area under curve; CSF k-FLC: concentration of kappa free light chains in cerebrospinal fluid (CSF); CSF λ-FLC: concentration of lambda free light chains in CSF; Q-k: CSF/serum quotient of concentrations of kappa free light chains; Q-λ: CSF/serum quotient of concentrations of lambda free light chains.
Table 2.
Receiver operator characteristic analysis of CSF free light chain (FLC) levels.
Table 3.
Concentrations of free light chains in CSF and serum and t-test results (data shown as median and IQR).
Fig 2.
Levels of intrathecal FLC in different groups.
CIS-MS: patients with clinically isolated syndrome that converted to multiple sclerosis after 2 years. CIS-nonMS: patients with clinically isolated syndrome that did not convert to multiple sclerosis after 2 years. NIND: patients with non-inflammatory neurologic diseases; ****−p<0.00001; **−p<0.01; *−p<0.05. Please also refer to Table 2 for more details.
Fig 3.
Concentration of k-FLCCSF and λ-FLCCSF in OCB-positive and OCB-negative patients in both CIS-MS and CIS-nonMS groups (data coupled).
CIS-MS: patients with clinically isolated syndrome who converted to multiple sclerosis after 2 years; CIS-nonMS: patients with clinically isolated syndrome who did not convert to multiple sclerosis after 2 years; OCB: oligoclonal bands.
Fig 4.
Concentrations of k-FLCCSF and λ-FLCCSF in OCB-positive patients in CIS-MS and CIS-nonMS groups.
CIS-MS: patients with clinically isolated syndrome who converted to multiple sclerosis after 2 years; CIS-nonMS: patients with clinically isolated syndrome who did not convert to multiple sclerosis after 2 years; OCB: oligoclonal bands.