Table 1.
Number of fully informative loci in 152 (near) triploid cases with vesicular chorionic villi, analyzed along with a maternal sample.
Fig 1.
SNP6 array analysis of individual C0301q and her twin pregnancy (C0301B (mole, PP) and C0301V (normal conceptus, PM)) demonstrating that the molar pregnancy was homozygous for all markers across the autosomal chromosomes and the X chromosome. Upper panel: Regions with stretches of markers showing homozygousity are displayed in purple. Lower panel: Genotypes (AA, AB, and BB) on chromosomes 1 for the three samples, illustrating the general absence of markers with genotype AB for the mole pregnancy. Each dot represents a genotyped SNP.
Table 2.
Parental types in triploid conceptuses with molar phenotype.
Fig 2.
reproduced [7]. Possible fertilizations, endoreduplications, and abnormal cell divisions in mosaic hydatidiform moles (HMs), and twin gestations including an HM.
(a) Fertilisation by two sperms; one giving rise to the paternal genome set in the diploid biparental cell population, the other giving rise to both genome sets in the diploid androgenetic cell population via endoreduplication. (b) Fertilisation by two sperms; one giving rise to one of the paternal genome sets in the diploid androgenetic cell population, the other contributing one genome set to both cell populations via endoreduplication. (c) Fertilisation by one sperm that via two endoreduplications gives rise to three identical paternal genome sets, of which two constitute the genome of the diploid androgenetic cell population and one is the paternal genome set in the diploid biparental cell population.