Table 1.
Patient characteristics and dose-adjusted concentrations and reciprocal ratios of CBZ and its major metabolites CBZE and CBZD.
CBZE: carbamazepine-10,11-epoxide; CBZD: 10,11-dihydroxy-carbazepine.
Fig 1.
Correlation between CBZ and CBZE plasma concentrations (Pearson’s correlation coefficient R).
Fig 2.
Graphical representation of adjusted odds ratio and 95% confidence intervals according to the SCN1A genes polymorphism; genotype and allele frequencies in epilepsy patients vs. healthy control subjects.
Fig 3.
Graphical representations (box-plot) of the sodium channels (SCN1A IVS5-91 G>A) SNPs genotypes associations with (A) CBZ daily dosage (mg/day), (B) CBZ maintenance dose (mg/kg per day), (C) CDRCBZ and (D) CBZD:CBZ.
Statistical significance for difference of means is shown (P values, one way ANOVA analysis followed by Student’s T-test).
Table 2.
CBZ daily dose, maintenance dose, concentration/dose adjusted ratios of CBZ, CBZE, CBZD and their concentration ratios stratified by individual SNPs genotypes.
Data are mean ± standard deviations.
Fig 4.
Graphical representations (box-plot) of the EPHX1 c.416A>G genotypes associations with (A) CBZD:CBZ, (B) CBZD:CBZE and (C) CDRCBZD,.
CBZ: Carbamazepine; CBZD: Carbamazepine-10,11-trans dihydrodiol; CBZE: Carbamazepine-10,11-epoxide; CDR: Concentration/dose ratio. Data are mean ± standard deviations. Statistical significance for difference of means is shown (P values, one way ANOVA analysis followed by Student’s T-test).
Fig 5.
Graphical representations (box-plot) of the EPHX1 c.377T>C genotypes with CDRCBZ CBZ: Carbamazepine; CDR: Concentration/dose ratio.
Data are mean ± standard deviations. Statistical significance for difference of means is shown (P values, one way ANOVA analysis followed by Student’s T-test).
Fig 6.
Graphical representations (box-plot) of the assessment of CBZ resistance due to patient response to therapy (A) CBZ daily dosage (mg/day), (B) CBZ maintenance dose (mg/kg per day) and (C) CBZ plasma concentration (μg/mL).
Data are mean ± standard deviations. Statistical significance for difference of means is shown (P values, Student’s T-test).
Table 3.
Distribution of SCN1A, ABCB1, EPHX1 genes polymorphism in drug-resistant and drug-responsive epileptic patients.