Table 1.
Clinical and demographical features of patient sample are shown in the upper part of the table.
Below that, brain areas presenting right, left or bilateral FDG-PET hypometabolism at the voxel-based SPM single-subject analysis are shown. M: male; F: female; MMSE: Mini Mental State Examination raw score; L and R: left and right hemisphere.
Table 2.
Performances of bvFTD patients on socio-emotional tasks are shown as adjusted scores according to the Italian normative data for both the Story-based Empathy Task (SET) and the Ek-60F (Ekman 60-Faces Task), and as raw scores for the Interpersonal Reactivity Index (IRI).
Equivalent scores = 0 (performance under the 5° percentile according to the Italian normative data) are shown in bold, while equivalent scores = 1 (performance between the 5° and the 10° percentile according to the Italian normative data) in italics. For IRI scores, values reported as cut-off are obtained using as reference score reported in [14]. SET GS: SET global score; SET-IA: SET Intention Attribution sub-scale score; SET-EA: SET Emotion Attribution sub-scale score; SET-CI: SET Causal Inferences sub-scale score; EK-60F GS: Ek60-F global score; ERA: emotion recognition and attribution index; IRI-PT: IRI Perspective Taking; IRI-F: IRI Fantasy; IRI-EC: IRI Empathic Concern; IRI-PD: IRI Personal Distress. N.E. = not evaluable for perseveration (# 16) or attention and/or working-memory disorders (# 4, 5, 6, 9). N.A. = not available.
Fig 1.
Temporal pole, inferior frontal gyrus, insula and nucleus accumbens FDG-PET hypometabolism in the 7 bvFTD patients impaired on social tasks.
Results are overlaid on the SPM structural MNI single-subject template and displayed on sagittal, coronal and axial view. The threshold is settled at p<0.001, minimal cluster extent = 100.
Fig 2.
Significant negative correlations between the ERA index and the right amygdala (A), temporal pole (B) and middle cingulate cortex (C) FDG-PET hypometabolism, and between Ek-60F disgust score and the bilateral insula hypometabolism.