Fig 1.
Effect of ABO blood type on the plasma levels of VWF, FVIII, prothrombin, fibrinogen, antithrombin and α2M in healthy subjects.
VWF (A) and FVIII (B) levels were significantly higher in non O blood groups. Prothrombin (C), fibrinogen (D) and antithrombin (E) levels did not differ between the blood groups, and α2M levels (F) were significantly lower in non O blood groups. Data represent individual measurements of donors divided into different ABO groups. * p<0.05, **p<0.01 and ***p<0.001.
Fig 2.
ABO blood type-dependency of the peak height and the ETP in platelet poor and platelet rich plasma.
Thrombin generation was measured at 1 pM TF in PRP (A-B) and at 1 pM TF (C-D) or 5 pM TF (E-F) in PPP. The peak height was increased in the non O blood groups in PPP and PRP (A-C-E). The ETP was significantly higher in the non O group, regardless of the TF concentration or the presence of platelets. Data represent individual measurements of donors divided into different ABO groups. * p<0.05 and **p<0.01.
Table 1.
Thrombin generation parameters in the ABO blood groups.
Fig 3.
Effect of ABO blood type on prothrombin conversion and thrombin inactivation.
The total amount of prothrombin converted was increased in the non-O blood groups (A), but the maximum rate of prothrombin conversion was statistically comparable between the groups (B). The total thrombin decay capacity was increased in the non-O blood group compared to the O group (C). Thrombin-antithrombin (T-AT) formation during TG is significantly increased in the non-O group, whereas the amount of thrombin-α2M (T-α2M) is comparable (D-E). However, the contribution of α2M to the inhibition of thrombin was increased in the O blood group (F). Data represent individual measurements of donors divided into different ABO groups. * p<0.05, **p<0.01 and ***p<0.001.