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Fig 1.

Classification of FDC at First Approval

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Fig 2.

FDC Potential Patent and Exclusivity Protection

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Table 1.

FDA-Approved NMEs and BLAs and NNE-FDC drugs by Therapeutic Category, 1980–2012.

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Table 1 Expand

Table 2.

FDA-Approved Non-NNE-FDC drugs by Therapeutic Category, 1980–2012.

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Table 2 Expand

Table 3.

Time Lag between Approval of Single Active Ingredient NME and FDC.

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Table 3 Expand

Table 4.

Time lag between FDC Drug Approval and Single Drug Generic Market Entry.

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Table 5.

Effective Patent and Exclusivity Life: FDCs Compared to Single Active Ingredient Included in Combination.

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Table 5 Expand