Table 1.
Dialyzers characteristics and performance.
Table 2.
Clinical and biochemical characteristics.
Table 3.
Kappa free light chain reduction ratio per patient and treatment protocol.
Fig 1.
Free light chain reduction ratio by modality of renal replacement therapy.
The left panel shows A) the crude reduction ratio (RR) of kappa free light chain by haemodialysis (HD) or haemodiafiltration (HDF) using large (2.1 m2) high cut-off filters (HCOL), small (1.1 m2) high cut-off filters (HCOS), and the 2.2 m2 heat sterilized high-flux polyphenylene HF (HF). Panel B shows the estimated marginal means of kappa reduction ratio taking into account repeated measurements within individuals and session duration using a GEE model. The percentages of the treatments with a kappa reduction ratio of ≥ 0.65 with each modality is shown in panel C. Panel D shows the percentages of the treatments with a kappa reduction ratio of ≥ 0.65 with each modality taking into account repeated measurements within individuals and session duration using a GEE model. The right panel shows the crude RR of lambda free light chain by renal replacement modality (E), and the estimated marginal means of lambda RR (F) taking into account repeated measures within individuals and session duration using GEE model. The crude and adjusted (within subjects and session duration) percentage of treatments with a lambda RR ≥0.65 are respectively shown in panels G and H. All p-values take into account adjustments for multiple comparisons using Bonferroni method.
Fig 2.
Impact of haemodiafiltration method of free light chain reduction ratio.
The impact of haemodiafiltration (HDF) in predilution (Pre), low-efficiency post-dilution (<15L post), and high-efficiency post-dilution (>15L post) are performed using large (2.1 m2) high cut-off filters (HCOL), small (1.1 m2) high cut-off filters (HCOS), and the 2.2 m2 heat sterilized high-flux polyphenylene HF (HF). The estimated marginal means of kappa (A) and lambda (B) light chain reduction ratio taking into account repeated measures and duration of each treatment session. P-values reported are adjusted for multiple comparisons using the Bonferroni correction method.* indicates that values are statistically different from other groups (P<0.01), ** indicates that values are statistically not different compared to other groups.
Table 4.
Lambda free light chain reduction ratio per patient and treatment protocol.
Fig 3.
Reduction ratio of molecules of increasing molecular weights.
The figure shows the reduction ratio (RR) of creatinine (113 Da), β-2 microglobulin (β2M, 11.8kDa), kappa (22.5 kDa) and lambda (45 kDa) free light chains, using haemodiafiltration with heat sterilized high-flux polyphenylene HF (HF-HDF), compared to haemodialysis or haemodiafiltration with a large (2.1 m2) high-cut-off dialyzer (HCOL). Estimates are obtained by generalized estimating equation taking into account repeated measures and session duration. * indicates a P-value of <0.05.