Fig 1.
Time course of aqueous MCP-1 (A) and IOP level (B).
Open circles with dotted line, trabeculectomy group; closed circles with solid line, Ex-PRESS tube shunt surgery group. Mean ± standard error. *P < 0.05, **P < 0.01, Dunnett’s test compared to non-operated eyes.
Fig 2.
Time course of bleb appearance.
(A) Representative photos after trabeculectomy (top) and Ex-PRESS tube shunt surgery (bottom). (B, C) Blebs were scored using the Moorfields Bleb Grading System. Open circles with dotted line, trabeculectomy group; closed circles with solid line, Ex-PRESS tube shunt surgery group. Mean ± standard error.
Fig 3.
Intensity of the bleb wall measured using anterior-segment optical coherence tomography.
Representative images in a horizontal scan 1 week after trabeculectomy (A) and Ex-PRESS tube shunt surgery (B). Time course of intensity. Open circles with dotted line, trabeculectomy group; closed circles with solid line, Ex-PRESS tube shunt surgery group. Mean ± standard error. *P < 0.05 by Wilcoxon rank-sum test.
Fig 4.
α-SMA-positive cells were detected as brown cells in the bleb after trabeculectomy (A, C) and Ex-PRESS tube shunt surgery (B, D). The red squares in A and B outline C and D (higher magnification), respectively. Scale bar, 1 mm (A, B) and 200 μm (C, D).