Fig 1.
NSCLC: Non Small Cell Lung Cancer; ADC:Adenocarcinoma; AdSqLC: Adenosquamous Lung carcinoma; SQ: Squamous Cell carcinoma; mADCs: mixed adenocarcinomas; ALK-R: ALK-rearrangments.
Table 1.
Clinical and pathological features of patients.
Table 2.
Clinical and pathological features of patients harboring mut-EGFRand ALK-R.
Table 3.
Clinical and Histological features of ALK-rearranged and EGFR-mutated patients.
Fig 2.
Representative results of the different areas of a mADC with coexistence of del E746-A750 EGFR and ALK-R (case 4).
Tumoral area of standard H&E slide with microphotographs of each single growth pattern is identified by different colored arrows/box. Acinar pattern: A, B, C, D. Papillary pattern: E, F, G, H. Lepidic pattern: I, L, M, N. Solid pattern: O, P, Q, R. Solid-signet ring cell pattern: S, T, U, V. In the first column: Hematoxylin and Eosin staining for each histological pattern (20X). In the second column: del E746-A750 EGFR immunopositivity in all patterns. (20X) The black arrows indicate the positive staining: acinar (B), papillary (F), lepidic (L), solid (P), signet (T). In the third column: ALK IHC results, acinar (C), papillary (G) and lepidic (M) patterns are negative; solid(Q) and solid-signet ring cell (U) patterns are positive, indicated by the black arrows. In the fourth column: ALK FISH results, acinar (D), papillary(H) and lepidic(N) are negative; solid pattern (R) shows the classic break-apart pattern with one fusion signal and two separated orange and green signals, indicated by the white arrows. Solid-signet ring cell pattern (V) shows the atypical FISH pattern with fused signals and one single red signal without a corresponding green signal, indicated by the white arrows.