Fig 1.
A 67 years old man with a suspicious high grade glioma in right temporal lobe on T1-weighted contrast-enhanced MRI. ROI 2 and ROI 3 were placed in the tumor parenchyma and peritumoral area, respectively; ROI 4 was put in the contralateral normal hemisphere.
Table 1.
Statistic description (Mean and interquartile range) of the different brain tumor types in tumor parenchyma (TP) and peritumoral (PT) area.
Fig 2.
ROC curves for significant permeability parameters and ADC.
Receiver operating characteristic (ROC) curves for significant permeability parameters and ADC in tumor parenchyma (Left) and peritumoral region (Right). In tumor parenchyma, Ve is the most powerful parameter to differentiate LGG from HGG, while in peritumoral area, only Ktrans showed significant difference in low- and high grade glioma.
Fig 3.
Comparison of HGG and LGG by ktrans and CTV.
A 24 years-old male with low grade gliomas (WHO I) near the fourth ventricle (a, b, c) and a 59 years-old male with high grade gliomas (WHO IV) in the left cerebellar hemisphere(d, e, f). Permeability parameter (Ktrans) maps of the tumors (a,d); concentration-time curve (CTV) of each tumor: the CTV of the low grade glioma manifested as plateau (b), the other one showed as a slowly rising curve(e); specific histologic type of each tumor: pilocytic astrocytoma (c) (Hematoxylin- Eosin(HE) ×4), small cell glioblastoma (f), (HE ×10).
Fig 4.
Description of primary central nervous system lymphoma by multiple parameters from diffusion and DCE-MR.
A 16 years old female with primary central nervous system lymphoma in the right frontal lobe. ADC map showed that the tumor had decreased signal intensity with peritumoral edema (a); tumor on contrast-enhanced T1-weighted MRI manifested as severe enhancement (b); the corresponding Ve (c) and iAUC (d) maps showed higher value in tumor parenchyma than peritumoral area; concentration-time curve (CTV) of the tumor manifested as a slowly rising type (e); histologic results: large B cell lymphoma (f), (Hematoxylin- Eosin(HE) ×10).
Fig 5.
Description of metastatic tumor by multiple parameters from DCE-MR.
A 72 years old male had a metastatic tumor in the left occipital lobe from renal cell carcinoma. Contrast-enhanced T1-weighted MRI showed that the tumor is obviously enhanced with severe peritumoral edema (a) and the corresponding Ktrans (b), Ve (c) and iAUC (d) maps were also showed high value inside tumor parenchyma except central necrosis; concentration-time curve of the tumor (e), it manifested as plateau; brain metastases from renal cell carcinoma (f), (Hematoxylin- Eosin(HE) ×4).
Table 2.
Parameters with the highest diagnostic prediction in tumor parenchyma (TP) and peritumoral area (PT) for distinction of a pair of brain tumors according to ROC analysis.
Table 3.
Detailed information of concentration-time curves (CTVs) with different brain tumor types.