Fig 1.
Phenotypic differentiation and senescence in the O and B populations.
(A) Female lifespan. (B) Male Lifespan. (C) Female food consumption. (D) Male food consumption. (E) Female phototaxis. (F) Male phototaxis. (G) Female chill coma recovery time. (H) Male chill coma recovery time. (I) Productivity. The B and O lines are color coded as indicated.
Fig 2.
Genome-wide DNA divergence between O and B lines.
The 95% quantiles of t-statistics within sliding windows of size 0.5Mb (by a sliding size of 0.1Mb) are plotted along the chromosome arms. The t-statistics are capped at 20 to enhance visualization of smaller differences.
Table 1.
Numbers of significant (FDR < 0.05) annotated genes for each term in the ANOVA models of gene expression.
Fig 3.
Genome-wide distribution of genes showing significant age, population, and age x population interaction effects on gene expression.
The proportions of genes showing significant age, population or age x population interaction effects within 0.5Mb non-overlapping windows are plotted along the chromosome arms. Genes are located by their mid-gene coordinates. The top and bottom panels are the distributions for females and males, respectively.
Fig 4.
Interaction plots showing signatures of postponed senescence.
Each plot shows the mean gene expression levels in normalized fragments per kilobase of exon per million fragments mapped (FPKM) at week 1 (W1) and week 5 (W5) in the B population (blue) and the O population (red). All examples are for male gene expression. See text for the description of the groups. (A) Group 1: CG6188 (interaction FDR = 5.57E-04). (B) Group 2: CG2233 (interaction FDR = 9.89E-06). (C) Group 3: Sfp53D (interaction FDR = 4.83E-06). (D) Group 4: CG31198 (interaction FDR = 8.72E-05). (E) Group 5: CR45054 (interaction FDR = 5.01E-05). (F) Group 6: CG6910 (interaction FDR = 3.63E-06). (G) Group 7: CG2930 (interaction FDR = 2.10E-05). (H) Group 8: Vap-33B (interaction FDR = 4.22E-03).