Table 1.
Derived1 allele frequencies and AMOVA results.
Table 2.
Correlation analysis results.
Fig 1.
Summary of the multifactor dimensionality reduction (MDR) interaction models.
(A) Interaction graphs comprised of nodes with pairwise connections between them. Values in nodes represent information gain (IG) of individual genes (main effect), while values between nodes are the IG of each pairwise combination (interaction effects). Positive entropy (plotted in red) indicates interaction (epistasis) and negative entropy (plotted in green or blue) indicates redundancy. Independence is represented by the gold color. (B) The MDM2-TP53 interaction associated with altitude in data set B. High-frequency genotype combinations in individuals who inhabit highlands (≥ 2,500 meters) are depicted as darkly shaded cells and low-frequency combinations in those individuals as lightly shaded. For each cell, the left bar indicates the absolute number of individuals who inhabit highlands and the right bar the absolute number of individuals who inhabit lowlands (< 2,500 meters).