Fig 1.
TNF-α (-308A/G), IL-10 (-1082G/A), IL-6 (-174G/C) gene polymorphism.
(1a) Lane 1–100 bp ladder;Lane 2–3;4–5;6–7;8-912-13-GA genotype; 10-11-GG genotype; respectively.(1b) Lane 1 – 100bp Ladder; Lane 2 &3 to 8& 9 –GA genotype; Lane 10&11 to 12&13 –GG genotype.(1c) Lane 100- 1000bp ladder;Lane 2-3-GC; 4-5-GC; 6–7,8-9-GG;10-11-CC;12-13-CC genotype.
Table 1.
Clinical characteristic of APTB, HHC and HC.
Fig 2.
Serum levels of TNF-α, IL-10, IL-6.
(2a, 2b, 2c) Data are shown as box plots, where the boxes represent the first through third quartiles, the lines within the boxes represent the median, and the lines outside the boxes represent the minimum and maximum values (excluding outliers). APTB- active pulmonary Tuberculosis patients; HHC-household contacts; HC-healthy controls.
Fig 3.
Comparison of cytokines in APTB, HHC and HC categories.
(a) Ratio of TNF-α/IL-10 serum levels (b) Ratio of IL-6/IL-10 serum levels. Results are represented as box plot. The threshold for significance was set at p ≤ 0.05. Bars above the plots represent the statistical differences between the groups.
Table 2.
ANOVA of TNF-α, IL-10 and IL-6.
Fig 4.
Comparision of cytokine gene polymorphisms of TNF-α (-308A/G), IL-10(-1082G/A) and IL-6(-174G/C) with serum levels.
(4a, 4b, 4c) Vertical axis- serum levels showing median values; Horizontal axis- genotypes of TNF- α (-308A/G); IL-10(-1082G/A) and IL-6(-174G/C),APTB—active pulmonary tuberculosis patients; HHC-household contacts; HC-healthy controls.
Table 3.
Comparison of TNF- α, IL-10 and IL-6 between patient (APTB) and Control (HC) groups.
Fig 5.
ROC plots for IL-10 and IL-6 for the comparison between patient (APTB) and control (HC) groups.